Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tango4Transport and golgi organization 4; It is involved in the biological process described with: mRNA splicing, via spliceosome; protein secretion; Golgi organization. (482 aa)    
Predicted Functional Partners:
Cdc5
Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.999
BCAS2
LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling.
   
 0.999
Prp19
Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation.
   
0.999
fand
Pre-mRNA-splicing factor syf1 homolog; Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of it [...]
   
 0.999
CG14641
LD46870p; pre-mRNA binding; mRNA binding; metal ion binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome.
   
 0.998
Bx42
Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway.
   
 0.998
crn
Crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis; Belongs to the crooked-neck family.
   
 0.997
CG12343
Pre-mRNA-splicing factor Syf2; Involved in pre-mRNA splicing as component of the spliceosome.
   
 0.996
c12.1
Protein CWC15 homolog; Involved in pre-mRNA splicing.
   
 0.994
CG8435
LD32459p; It is involved in the biological process described with: RNA splicing.
   
 
 0.994
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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