Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
Cyp311a1Probable cytochrome P450 311a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (483 aa)    
Predicted Functional Partners:
Cyp18a1
Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1.
  
 
0.570
phm
Phantom (phm) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It is an endoplasmic reticulum protein that catalyzes the addition of a hydroxyl group to the 25 carbon of the cholesterol side chain. phm mutants fail to undergo head involution, dorsal closure and cuticle secretion.
  
 
0.536
Cyp304a1
Probable cytochrome P450 304a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.462
Cyp9h1
Probable cytochrome P450 9h1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
  
0.437
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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