STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TomosynTomosyn, isoform C; Tomosyn (Tomosyn) encodes a protein involved in long-term memory and neuromuscular synaptic transmission. (1470 aa)    
Predicted Functional Partners:
Syx1A
Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Required for coordinated peristaltic contractions. Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens [...]
   
 0.964
Syx4
Syntaxin-4; Syntaxin 4 (Syx4) encodes a member of the superfamily of SNARE genes, which mediate membrane fusion. The product of Syx4 is associated with Golgi to plasma membrane transport as well as acting as a plasma membrane t-SNARE to regulate synaptic growth at the neuromuscular junction.
    
 0.960
Snap25
Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family.
   
 0.944
cpx
Complexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release; Belongs to the complexin/synaphin family.
     
 0.902
Snap24
Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family.
   
 0.899
Syb
Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.
    
 0.877
unc-13
Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis.
   
  
 0.873
gammaSnap2
Soluble NSF attachment protein activity; syntaxin binding. It is involved in the biological process described with: synaptic vesicle priming; neurotransmitter secretion; intracellular protein transport.
    
 0.809
gammaSnap1
Gamma Soluble NSF attachment protein 1 (gammaSnap1) encodes a protein involved in the dorsal/ventral pattern formation of the wing disc.
    
 0.800
Syx6
Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity.
   
 0.794
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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