STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Agpat11-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: phosphatidic acid biosynthetic process; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (343 aa)    
Predicted Functional Partners:
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase activity; transferase activity, transferring acyl groups.
     
 0.993
mino
Minotaur, isoform A; Minotaur (mino) encodes a member of the conserved glycerol-3-phosphate O-acyltransferase family, which converts glycerol-3-phosphate into lysophosphatidic acid. It functions in phosphatidic acid biosynthesis. It is also essential for piRNA biogenesis in gonads, with mino mutants showing transposon de-repression and sterility phenotypes; Belongs to the GPAT/DAPAT family.
  
 
 0.989
Agpat4
Transferase activity, transferring acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase activity.
     
 0.987
Gpat4
Glycerol-3-phosphate acyltransferase 4 (Gpat4) encodes a de novo synthase of lysophosphatidic acid.
   
 
 0.987
CG15450
PlsC domain-containing protein; Glycerol-3-phosphate O-acyltransferase activity.
   
 
 0.970
Lpin
Lipin, isoform A; Lipin (Lpin) encodes a protein that plays a central role in fat body function and energy metabolism. It works as a phosphatidate phosphatase required for normal insulin pathway signaling.
     
 0.961
Dgkepsilon
Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid.
     
 0.952
CG31140
Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity.
     
 0.952
Dgk
Diacylglycerol kinase 1; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons.
     
 0.934
Cds
Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...]
     
 0.930
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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