STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG1673Branched-chain-amino-acid transaminase activity. It is involved in the biological process described with: valine biosynthetic process; branched-chain amino acid biosynthetic process; leucine biosynthetic process; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (443 aa)    
Predicted Functional Partners:
CG8199
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.992
Eip55E
Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis.
  
 0.971
Hmgcl
3-Hydroxymethyl-3-methylglutaryl-CoA lyase, isoform A; hydroxymethylglutaryl-CoA lyase activity. It is involved in the biological process described with: leucine metabolic process; leucine catabolic process; lipid metabolic process; ketone body biosynthetic process.
  
 
 0.966
CG17691
Uncharacterized protein, isoform C; Alpha-ketoacid dehydrogenase activity. It is involved in the biological process described with: response to nutrient; fatty-acyl-CoA biosynthetic process; branched-chain amino acid catabolic process.
  
 0.960
CG11241
IP18034p; Pyridoxal phosphate binding; alanine-glyoxylate transaminase activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.953
Srr
Serine racemase, isoform B; Serine racemase activity; L-serine ammonia-lyase activity; L-threonine ammonia-lyase activity. It is involved in the biological process described with: threonine catabolic process; L-serine catabolic process.
  
 
 0.934
Gclm
Glutamate-cysteine ligase modifier subunit (Gclm) encodes a protein that regulates the ligase activity of the product of Gclc. It is involved in glutathione biosynthesis, arsenic detoxification and response to ethanol.
  
 0.906
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  
 
 0.905
Gclc
Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine; Belongs to the glutamate--cysteine ligase type 3 family.
   
 
 0.901
Hacl
Magnesium ion binding; carbon-carbon lyase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: fatty acid alpha-oxidation; Belongs to the TPP enzyme family.
  
 
 0.899
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.