Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG9941LP12254p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (789 aa)    
Predicted Functional Partners:
dsd
Distracted, isoform B; It is involved in the biological process described with: animal organ morphogenesis; synaptic target recognition; tissue development.
   
 
 0.941
CG5334
Ubiquitin-protein transferase activity; zinc ion binding; metal ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination.
    
 
 0.922
TSG101
Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles.
    
 
 0.901
Mkrn1
Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis.
      
 0.862
CG33785
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
      
 0.783
Sin
Sex-lethal interactor, isoform A; Protein binding; DNA-directed 5'-3' RNA polymerase activity. It is involved in the biological process described with: transcription, DNA-templated.
      
 0.753
Nprl3
GATOR complex protein NPRL3; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...]
      
 0.683
RhoGAP92B
Rho GTPase-activating protein 92B; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
      
 0.661
CG14182
MIP13743p; It is involved in the biological process described with: negative regulation of smoothened signaling pathway.
    
 
 0.650
Smurf
E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.
   
 
 0.648
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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