node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG3473 | CG4968 | FBpp0310283 | FBpp0079577 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | 0.917 |
CG3473 | Diap2 | FBpp0310283 | FBpp0086431 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | 0.931 |
CG3473 | RpL40 | FBpp0310283 | FBpp0306837 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.897 |
CG3473 | RpS27A | FBpp0310283 | FBpp0079606 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.907 |
CG3473 | STUB1 | FBpp0310283 | FBpp0079617 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. | 0.919 |
CG3473 | Tak1 | FBpp0310283 | FBpp0077011 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis. | 0.688 |
CG3473 | Traf6 | FBpp0310283 | FBpp0071136 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. | 0.946 |
CG3473 | Uba1 | FBpp0310283 | FBpp0087583 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.918 |
CG3473 | Uev1A | FBpp0310283 | FBpp0076859 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.999 |
CG3473 | ben | FBpp0310283 | FBpp0298297 | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. | 0.901 |
CG4968 | CG3473 | FBpp0079577 | FBpp0310283 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | 0.917 |
CG4968 | RpL40 | FBpp0079577 | FBpp0306837 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.951 |
CG4968 | RpS27A | FBpp0079577 | FBpp0079606 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.913 |
CG4968 | Traf6 | FBpp0079577 | FBpp0071136 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. | 0.656 |
CG4968 | Uev1A | FBpp0079577 | FBpp0076859 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.630 |
CG4968 | ben | FBpp0079577 | FBpp0298297 | Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family. | Bendless (ben) encodes an E2 ubiquitin-conjugating enzyme. It plays essential roles in multiple processes such as synaptic growth and maturation, axon guidance, innate immunity, genomic integrity, tumor growth, cell invasion, apoptosis, long-term memory and escape response. | 0.921 |
Diap2 | CG3473 | FBpp0086431 | FBpp0310283 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | GEO08666p1; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination; protein K63-linked ubiquitination; postreplication repair; Belongs to the ubiquitin-conjugating enzyme family. | 0.931 |
Diap2 | RpL40 | FBpp0086431 | FBpp0306837 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.672 |
Diap2 | RpS27A | FBpp0086431 | FBpp0079606 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.752 |
Diap2 | STUB1 | FBpp0086431 | FBpp0079617 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] | Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. | 0.430 |