STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG14411FI17948p1; Phosphatidylinositol-3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; defense response to Gram-negative bacterium. (843 aa)    
Predicted Functional Partners:
mtm
Myotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling.
  
0.936
be
Ben, isoform C; Ben (be) encodes a protein involved in neuromuscular synaptic transmission and long-term memory formation.
   
 
 0.690
dob
Doppelganger von brummer; Triglyceride lipase activity. It is involved in the biological process described with: lipid homeostasis; triglyceride catabolic process.
   
  
 0.606
CG15027
Translation machinery-associated protein 16 homolog; Belongs to the UPF0534 family.
      
 0.606
CG32812
EG:114D9.1 protein; Calcium ion binding. It is involved in the biological process described with: negative regulation of phosphatase activity.
    
 
 0.563
TbCMF46
TbCMF46.
    
 
 0.553
CG17598
GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.
   
  
 0.540
Ptp36E
Protein tyrosine phosphatase 36E (Ptp36E) encodes a tyrosine-specific protein phosphatase. It is probably a cytoplasmic protein, as it lacks a predicted transmembrane domain, but little is known about its function.
   
  
 0.534
PpV
Protein phosphatase V (PpV) encodes the catalytic subunit of the protein phosphatase 6 (PP6), which negatively regulates JNK and AMPK signaling. PpV product is essential for lipid homeostasis and Ras-induced tumorigenesis; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
   
 
 0.526
CG31469
GEO10716p1; Protein arginine phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: peptidyl-N-phospho-arginine dephosphorylation.
      
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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