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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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CG9065LP17418p; Copper chaperone activity. It is involved in the biological process described with: copper ion transport; respiratory chain complex IV assembly; mitochondrial cytochrome c oxidase assembly. (88 aa)    
Predicted Functional Partners:
CG7950
GEO12235p1; Protein disulfide oxidoreductase activity. It is involved in the biological process described with: protein maturation by protein folding; protein import into mitochondrial intermembrane space.
   
 
 0.972
Scox
Synthesis of cytochrome c oxidase (Scox) encodes a protein involved in cytochrome complex assembly and regulation of ATP biosynthesis.
   
 0.971
pum
Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...]
    
 
 0.968
CG31648
RE57459p; Copper ion binding. It is involved in the biological process described with: aerobic respiration; respiratory chain complex IV assembly.
   
 
 0.925
CG13018
GEO10184p1; It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly.
   
 
 0.901
Atox1
Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body.
   
 
 0.891
CG42496
LD37882p1; Copper ion binding. It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly; metal ion transport.
     
 0.881
Ccs
Copper chaperone for superoxide dismutase (Ccs) encodes a protein required for the proper superoxide dismutase function of the product of Sod1. It is involved in determination of lifespan, oxidative stress, and cytosolic aconitase activity.
   
  
 0.868
mt:CoII
Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]
     
 0.851
Surf1
SURF1-like protein; Surfeit 1 (Surf1) encodes a nuclear gene encoding a protein that might be involved in the assembly of the mitochondrial respiratory chain Cytochrome Oxidase (COX or Complex IV). Mutations in its human ortholog Surf1 are related to Leigh Syndrome with COX deficiency (LScox). Surf1 RNAi knockdown produces many of the hallmark signs of LScox, albeit with a more complex biochemical profile.
   
 
 0.850
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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