Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG7872DnaJ homolog subfamily C member 25 homolog; It is involved in the biological process described with: protein folding. (333 aa)    
Predicted Functional Partners:
CG3184
GH14157p; Demethylase activity. It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine.
      
 0.742
CG44303
Uncharacterized protein.
      
 0.742
Slu7
Pre-mRNA-splicing factor Slu7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
   
  
 0.654
CG5098
Uncharacterized protein CG5098; Transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II.
   
 
 0.605
RpS13
Ribosomal protein S13 (RpS13) encodes a structural constituent of ribosomes; Belongs to the universal ribosomal protein uS15 family.
   
 
 0.574
Roe1
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.535
GCS1
Glucosidase 1, isoform B; Mannosyl-oligosaccharide glucosidase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide metabolic process.
    
 
 0.513
aux
Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death.
    
 
 0.505
Pbgs
Delta-aminolevulinic acid dehydratase; Zinc ion binding; porphobilinogen synthase activity. It is involved in the biological process described with: heme biosynthetic process; Belongs to the ALAD family.
     
 0.503
Pfdn1
Prefoldin 1, isoform A; Unfolded protein binding; protein folding chaperone. It is involved in the biological process described with: protein folding.
      
 0.498
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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