STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
StimStromal interaction molecule, isoform a; Stromal interaction molecule homolog; Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores (570 aa)    
Predicted Functional Partners:
olf186-F
Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import
   
 0.999
Itp-r83A
Inositol 1,4,5,-trisphosphate receptor, isoform b; Inositol 1,4,5,-tris-phosphate receptor (Itp-r83A) is an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itp-r83A depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight
    
 0.997
Ca-P60A
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase is an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage
   
 
 0.980
trp
Transient receptor potential protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development; Bel [...]
    
 0.970
Cam
Calmodulin, isoform c; Calmodulin is a Calcium-binding messenger protein. It acts as a part of the calcium signal transduction pathway and interacts with various target proteins such as kinases or phosphatases. It is involved in actin filament-based movement, mitotic spinde assembly, axon guidance, DNA damage response, autophagy, cell death, sensory perception, and muscle homeostasis
      
 0.951
Tm2
Tropomyosin 2, isoform f; Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis
      
 0.913
jp
Junctophilin, isoform A; Junctophilin
      
 0.904
NFAT
NFAT nuclear factor, isoform B; Sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with: regulation of response to DNA damage stimulus; negative regulation of Ras protein signal transduction; negative regulation of synaptic vesicle exocytosis; imaginal disc-derived wing morphogenesis; transcription, DNA-templated; regulation of transcription, DNA-templated; response to salt stress
      
 0.900
Trpgamma
Transient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily
    
 0.840
RyR
Ryanodine receptor; Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles; Belongs to the ryanodine receptor (TC 1.A.3.1) family
      
 0.815
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, fruit fly
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