STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CalpCCalpain-C; Calpain C (CalpC) encodes one of four calcium-dependent cysteine proteases, but lack of conservation in the catalytic domain suggests it lacks proteolytic activity. (681 aa)    
Predicted Functional Partners:
pip
Heparan sulfate 2-O-sulfotransferase pipe; Sulfotransferase involved in dorsoventral axis patterning in early embryos. Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell. Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade.
      
 0.626
CG17765
GH27120p; Calcium ion binding.
   
 
0.587
Alg-2
Apoptosis-linked gene-2; Calcium ion binding. It is involved in the biological process described with: positive regulation of JNK cascade.
   
 
0.587
parvin
Parvin, isoform A; Parvin (parvin) encodes a Calponin-homology protein that, together with the products of Ilk and stck, reinforces integrin-matrix adhesion at muscle attachment sites in the developing embryo. The product of parvin contributes to cell adhesion and actin cytoskeleton organisation in muscles, wing and eye epithelial cells.
   
 
 0.498
CalpA
Calpain-A catalytic subunit; Calpain-A (CalpA) encodes a calcium-dependent modulatory protease that cleaves its substrates in a limited fashion. During patterning and division in the blastoderm embryo, CalpA product cleaves the NF-kappaB inhibitor and the cell cycle regulator encoded by cact and CycB, respectively. CalpA product also regulates dendritic prunning of sensory neurons.
  
 
 
0.489
CalpB
Calpain-B catalytic subunit 1; Calcium-regulated non-lysosomal thiol-protease.
  
 
 
0.476
wech
Wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link.
      
 0.465
CG5731
Alpha-galactosidase activity. It is involved in the biological process described with: oligosaccharide metabolic process; glycoside catabolic process; glycosylceramide catabolic process.
      
 0.461
fwe
Calcium channel flower; Flower (fwe) encodes a transmembrane protein with different isoforms expressed in 'loser' and in 'winner' cells to mediate win/lose decisions in cell competition and neuronal culling during development and ageing.
      
 0.433
sol
Calpain-D; Has a role in eye development; Belongs to the peptidase C2 family.
   
  
0.416
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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