STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)    
Predicted Functional Partners:
drk
Protein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory).
   
0.976
Shc
SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development.
    
 0.963
Pi3K92E
Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family.
   
 0.963
Pten
Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements.
   
 0.952
Ocrl
Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis.
   
 0.939
IP3K1
Kinase; Inositol 1,4,5-triphosphate kinase 1 (IP3K1) encodes a protein involved in response to oxidative stress; Belongs to the inositol phosphokinase (IPK) family.
     
 0.939
norpA
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...]
     
0.937
IP3K2
Kinase; Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling; Belongs to the inositol phosphokinase (IPK) family.
     
 0.937
Dgkepsilon
Diacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid.
     
 0.929
5PtaseI
5PtaseI, isoform C; Inositol-polyphosphate 5-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; phosphatidylinositol dephosphorylation.
   
 
 0.928
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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