Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CG12395CG12395-PA; Microtubule binding. It is involved in the biological process described with: regulation of cytoskeleton organization. (254 aa)    
Predicted Functional Partners:
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
    
 
 0.608
Rsph3
GH13213p.
  
 
 0.503
Spag1
Spag1 axonemal dynein assembly factor; Heat shock protein binding. It is involved in the biological process described with: protein targeting to mitochondrion.
    
 
 0.502
Rsph9
AT29119p; It is involved in the biological process described with: axoneme assembly; cilium movement involved in cell motility; motile cilium assembly.
  
   0.487
CG17687
Uncharacterized protein.
   
 
 0.476
SpdS
Spermidine synthase activity. It is involved in the biological process described with: polyamine biosynthetic process; spermidine biosynthetic process; Belongs to the spermidine/spermine synthase family.
   
  
 0.471
w
White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker.
    
 
 0.465
klhl10
Kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation.
    
 
 0.465
Efhc1.1
EF-hand domain containing 1.1; It is involved in the biological process described with: regulation of neuron projection development; regulation of dendrite morphogenesis; synaptic growth at neuromuscular junction.
  
 
 0.462
CG13693
DUF4201 domain-containing protein.
   
   0.459
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.