Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RokRho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. (1390 aa)    
Predicted Functional Partners:
Rho1
Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...]
    
 0.999
sqh
Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis.
    
 0.958
dsh
Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.
   
 0.944
Mlc2
Myosin light chain 2 (Mlc2) encodes a subunit of the myosin complex involved in myofibril assembly. It contributes to different flight-related processes including wing beat frequency, and indirect flight muscle contraction.
    
 
 0.941
Mbs
Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis.
   
 0.937
dia
Protein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.
   
 0.935
fz
Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...]
   
 0.935
DAAM
Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons.
   
 0.930
zip
Myosin heavy chain, non-muscle; Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment. Interaction with the myosin ck may be important for this function. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.926
LIMK1
LIM domain kinase 1 (LIMK1) encodes a protein that belongs to a phylogenetically conserved family of serine/threonine kinases. It is a potent stabilizer of the actin cytoskeleton by inactivating the product of tsr. It stabilizes the synapse structure at the neuromuscular junction and promotes synaptic remodeling and glomerular development in the developing antennal lobe.
   
 
0.926
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.