STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cnx14DCalnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. (639 aa)    
Predicted Functional Partners:
Uggt
UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family.
   
 
 0.949
Gp93
Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development.
   
 
 0.920
Hsc70-3
Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity).
   
 
 0.915
CG1924
Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response.
  
 
 
0.915
Calr
Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).
   
 
0.878
Sec63
Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation.
   
 
 0.826
Edem1
alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as "ER-Associated Degradation"; Belongs to the glycosyl hydrolase 47 family.
   
 
 0.824
Lamp1
FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle.
    
 
 0.822
Itpr
Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family.
    
 
 0.795
GCS2alpha
Glucan 1,3-alpha-glucosidase activity; carbohydrate binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family.
    
 
 0.793
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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