STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
mthl1Methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. (676 aa)    
Predicted Functional Partners:
mthl14
Probable G-protein coupled receptor Mth-like 14; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
      
 0.838
cta
Guanine nucleotide-binding protein subunit alpha homolog; May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes; Belongs to the G-alpha family. G(12) subfamily.
   
 
 0.684
CG43739
annotation not available
      
 0.658
CG46306
Uncharacterized protein.
      
 0.658
mthl7
Probable G-protein coupled receptor Mth-like 7; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; response to starvation; Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
      
 0.629
smog
Smog, isoform D; Smog (smog) encodes a G-protein-coupled receptor with a key role in gastrulation. It contributes to cell intercalation and apical constriction via myosin II activation.
      
 0.604
mthl13
Methuselah-like 13; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway.
      
 0.516
krz
Kurtz, isoform A; Kurtz (krz) encodes a beta-arrestin (non-visual arrestin) involved in the desensitization and endocytic internalization of G protein coupled receptors, thus downregulating their activity. It also controls other signaling pathways, including Notch, receptor tyrosine kinase, Hedgehog, and Toll. It is required maternally for normal embryonic patterning and zygotically for larval viability.
    
 
 0.504
att-ORFB
AT07308p.
      
 0.497
CG30288
RT07670p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
      
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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