STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
singSingles bar (sing) encodes a small multipass transmembrane protein that is required for muscle fusion in embryonic and adult stages. It is needed for progression beyond the pre-fusion complex stage of myoblast fusion, possibly by delivering fusion machinery components by vesicle fusion. (176 aa)    
Predicted Functional Partners:
siz
Schizo, isoform B; Schizo (siz) encodes an Arf1 guanine nucleotide exchange factor involved in commissural axon guidance and myoblast fusion.
      
 0.660
mbc
Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family.
      
 0.604
kirre
Kin of irre (kirre) encodes a transmembrane protein of the Ig superfamily that is involved in heterotypic interactions with the product of sns. Interactions with intracellular adaptors regulate cytoskeleton dynamics. Its biological roles include myoblast aggregation and fusion, nephrocyte diaphragm formation, and cell sorting in the eye and wing imaginal discs.
      
 0.601
CG15211
RE01453p.
      
 0.550
lmd
Lame duck (lmd) encodes a zinc finger transcription factor expressed in the embryonic somatic and visceral mesoderm, where it is essential for the specification of fusion competent myoblasts and for myoblast fusion.
   
  
 0.545
rols
Rolling pebbles (rols) encodes a protein required for myoblast fusion in founder cells. it interacts with the membrane spanning Immunoglobulin superfamily protein encoded by kirre and with the product of Mhcl.
   
  
 0.541
Crk
Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family.
      
 0.491
Whamy
WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion.
      
 0.465
WASp
WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis.
      
 0.463
CG9815
Uncharacterized protein, isoform B.
      
 0.461
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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