STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTLL1ATubulin tyrosine ligase-like 1A; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation. (496 aa)    
Predicted Functional Partners:
Edc3
Enhancer of mRNA-decapping protein 3; In the process of mRNA degradation, may play a role in mRNA decapping.
    
 
 0.885
DCP2
Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly.
    
 
 0.777
Dnali1
Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility.
  
  
 0.729
betaTub56D
Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.
    
 
 0.692
spas
Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.
      
 0.685
DCP1
Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing.
    
 
 0.675
Nna1
Nna1 carboxypeptidase (Nna1) encodes a highly conserved cytoplasmic carboxypeptidase. Nna1 loss leads to neurodegeneration by causing mitochondrial dysfunction. It has been proposed to function as protein-deglutamylases, possibly interacting with and modifying tubulin.
  
   
 0.610
TTLL5
Tubulin tyrosine ligase-like 5, isoform A; Protein-glycine ligase activity; tubulin-glutamic acid ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; C-terminal protein amino acid modification; protein polyglycylation; protein polyglutamylation.
  
   
0.598
CG6931
GH25848p; It is involved in the biological process described with: protein polyglutamylation.
   
 
 0.567
Tektin-A
Tektin A, isoform A; It is involved in the biological process described with: cilium movement involved in cell motility; cilium assembly.
   
  
 0.559
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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