STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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e(y)1Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. (278 aa)    
Predicted Functional Partners:
Tbp
TATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex.
   
 0.999
Taf6
TBP-associated factor 6 (Taf6) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it might be important for its stability. It forms a histone-like pair with the product of e(y)1. It is required during all stages of development, but particularly during imaginal disc development and gametogenesis.
   
 0.999
Taf2
TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements.
   
 0.999
Saf6
SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities.
   
 0.999
Taf11
TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex.
   
 0.999
Ada1-2
Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex.
   
 0.999
Taf13
TBP-associated factor 13; DNA binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; transcription coregulator activity. It is involved in the biological process described with: transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II.
   
 0.999
Taf12
TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex.
   
 0.999
Spt3
FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex.
   
 0.999
wda
Will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5.
   
 0.999
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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