Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Cyp308a1Probable cytochrome P450 308a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (490 aa)    
Predicted Functional Partners:
sad
Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
 0.673
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.585
Jhedup
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
   
  
 0.574
Cyp305a1
Probable cytochrome P450 305a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.550
Cyp12e1
Probable cytochrome P450 12e1, mitochondrial; Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.
  
 
   0.545
Cyp301a1
Probable cytochrome P450 301a1, mitochondrial; Cyp301a1 (Cyp301a1) encodes a member of the cytochrome P450 family, which have both mitochondrial and cytosolic roles in the detoxification of compounds.
  
 
 
 0.543
Cyp313b1
Probable cytochrome P450 313b1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
   
 0.535
shd
Ecdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family.
  
 
   0.530
CG42284
Uncharacterized protein, isoform D.
   
 
 0.507
GstE4
Glutathione S transferase E4 (GstE4) encodes an enzyme involved in glutathione metabolic processes; Belongs to the GST superfamily.
   
  
 0.499
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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