Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mec2SD05291p; Protein binding. It is involved in the biological process described with: nephrocyte filtration. (350 aa)    
Predicted Functional Partners:
Piezo
Piezo-type mechanosensitive ion channel component; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Plays a major role in nociception (response to strong or painful touch) ; Belongs to the PIEZO (TC 1.A.75) family.
      
 0.663
cindr
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis.
    
 
 0.645
CG15674
Uncharacterized protein, isoform A.
   
  
 0.611
CG14456
Uncharacterized protein, isoform B.
      
 0.599
CG8490
FI16743p1.
      
 0.599
kirre
Kin of irre (kirre) encodes a transmembrane protein of the Ig superfamily that is involved in heterotypic interactions with the product of sns. Interactions with intracellular adaptors regulate cytoskeleton dynamics. Its biological roles include myoblast aggregation and fusion, nephrocyte diaphragm formation, and cell sorting in the eye and wing imaginal discs.
      
 0.599
CG17712
BcDNA.GH03377; Oxidoreductase activity.
      
 0.598
CG9902
Uncharacterized protein, isoform A.
      
 0.598
CG14629
GH18858p.
   
 
 0.562
CG8157
Uncharacterized protein, isoform A.
      
 0.530
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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