Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG7990Post-GPI attachment to proteins factor 2-like; It is involved in the biological process described with: GPI anchor biosynthetic process. (325 aa)    
Predicted Functional Partners:
PGAP3
Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling.
    
 0.970
CG4025
EG:22E5.9 protein; It is involved in the biological process described with: regulation of autophagy.
      
 0.912
PGAP2
Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family.
  
  
 
0.910
CG15880
Uncharacterized protein; It is involved in the biological process described with: GPI anchor biosynthetic process.
     
  0.900
Ttc7
Tetratricopeptide repeat domain 7, isoform A; It is involved in the biological process described with: phosphatidylinositol phosphorylation; protein localization to plasma membrane.
      
 0.811
GCS1
Glucosidase 1, isoform B; Mannosyl-oligosaccharide glucosidase activity. It is involved in the biological process described with: protein N-linked glycosylation; oligosaccharide metabolic process.
   
 
 0.799
Pi4KIIalpha
Pi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland.
      
 0.598
Pi4KIIIalpha
Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family.
   
  
 0.597
PIG-C
Phosphatidylinositol glycan anchor biosynthesis class C (PIG-C) encodes a subunit of GPI-GlcNAc transferase, which catalyzes the first reaction in the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor.
   
  
 0.537
PGAP5
Metallophosphoesterase 1 homolog; Post-GPI attachment to proteins 5 (PGAP5) encodes a protein that belongs to a dimetal-containing phosphoesterase family and catalyzes the remodeling of the glycan moiety on glycosylphosphatidylinositol (GPI)-anchored proteins. Its catalytic activity is a prerequisite for the efficient exit of GPI-anchor proteins from the ER; Belongs to the metallophosphoesterase superfamily. MPPE1 family.
    
 
 0.502
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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