STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7423IP06248p; Sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of cell growth; regulation of barbed-end actin filament capping. (124 aa)    
Predicted Functional Partners:
Vha16-4
V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
   
  
 0.893
cpb
Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.
    
 
 0.870
cpa
Capping protein alpha (cpa) encodes an actin-binding protein that, along with the product of cpb, binds to the fast growing ends of actin filaments to restrict the addition or loss of actin monomers. It limits the nuclear translocation of the Hippo pathway mediator encoded by yki and restricts JNK signaling. It maintains epithelial integrity and controls the balance between proliferation and apoptosis in the wing imaginal disc. It plays important roles during oogenesis, as well as maintaining neuronal homeostasis.
   
 
 0.749
CG5157
GEO11555p1; Electron transfer activity; heme binding; Belongs to the cytochrome b5 family.
    
   0.700
CG6036
Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.
   
 
 0.698
CG14259
IP09473p.
    
   0.697
ND-49L
NADH dehydrogenase activity; quinone binding; NADH dehydrogenase (ubiquinone) activity; NAD binding. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone; Belongs to the complex I 49 kDa subunit family.
  
 
 0.660
cerv
Cervantes, isoform A; Zinc ion binding; SUMO transferase activity. It is involved in the biological process described with: DNA repair; double-strand break repair via homologous recombination.
      
 0.659
Prosbeta5R1
Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process.
   
 
 0.637
Prosalpha3T
Proteasome subunit alpha type-4-like; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
   
 
 0.576
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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