STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pfrx6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form; ATP binding; 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity. It is involved in the biological process described with: glycolytic process; fructose metabolic process; fructose 2,6-bisphosphate metabolic process; carbohydrate phosphorylation. (716 aa)    
Predicted Functional Partners:
Pfk
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 0.969
fbp
Fructose-1,6-bisphosphatase, isoform F; Fructose 1,6-bisphosphate 1-phosphatase activity. It is involved in the biological process described with: gluconeogenesis; fructose 6-phosphate metabolic process; fructose metabolic process; fructose 1,6-bisphosphate metabolic process; sucrose biosynthetic process; Belongs to the FBPase class 1 family.
   
 
 0.959
Hex-C
Phosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis.
   
 0.924
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
   
 0.922
Hex-t1
Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
   
 0.922
Hex-t2
Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
   
 0.922
Mpi
Zinc ion binding; mannose-6-phosphate isomerase activity. It is involved in the biological process described with: GDP-mannose biosynthetic process; carbohydrate metabolic process.
  
 
 0.914
CG8078
Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
      0.774
Pgi
Phosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis.
  
  
 0.740
Eno
Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family.
     
 0.672
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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