Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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Pfrx6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form; ATP binding; 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity. It is involved in the biological process described with: glycolytic process; fructose metabolic process; fructose 2,6-bisphosphate metabolic process; carbohydrate phosphorylation. (716 aa)    
Predicted Functional Partners:
Pfk
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 0.974
fbp
Fructose-1,6-bisphosphatase, isoform F; Fructose 1,6-bisphosphate 1-phosphatase activity. It is involved in the biological process described with: gluconeogenesis; fructose 6-phosphate metabolic process; fructose metabolic process; fructose 1,6-bisphosphate metabolic process; sucrose biosynthetic process; Belongs to the FBPase class 1 family.
   
 
 0.971
Hex-C
Phosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis.
   
 0.926
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
   
 0.922
Hex-t1
Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
   
 0.922
Hex-t2
Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
   
 0.922
Mpi
Zinc ion binding; mannose-6-phosphate isomerase activity. It is involved in the biological process described with: GDP-mannose biosynthetic process; carbohydrate metabolic process.
  
 
 0.912
CG8078
Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
    
 0.779
Hmgcr
3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family.
      
 0.628
MESR3
Misexpression suppressor of ras 3, isoform B; RNA polymerase II cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
 
 0.626
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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