STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MKP-4Dual specificity protein phosphatase MPK-4; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response. (387 aa)    
Predicted Functional Partners:
CG13197
RE27552p; Protein tyrosine/serine/threonine phosphatase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
   
  
 0.670
CG12299
LD46233p; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II.
   
   0.665
PPP4R2r
Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
   
  
 0.611
PTP-ER
Protein tyrosine phosphatase-ERK/Enhancer of Ras1 (PTP-ER) encodes a phosphatase required for mitosis. It is involved in RAS/MAPK signaling regulation and eye development.
   
 
 0.579
CG3530
GH09546p; Metal ion binding; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; mitotic cell cycle; regulation of autophagy.
   
 
 0.576
CG31469
GEO10716p1; Protein arginine phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: peptidyl-N-phospho-arginine dephosphorylation.
   
 
 0.568
PpV
Protein phosphatase V (PpV) encodes the catalytic subunit of the protein phosphatase 6 (PP6), which negatively regulates JNK and AMPK signaling. PpV product is essential for lipid homeostasis and Ras-induced tumorigenesis; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
   
 
 0.561
CG5026
LD06050p; Phosphatidylinositol-3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; negative regulation of autophagy.
   
 
 0.558
CG42327
IP14232p; Protein tyrosine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.552
CG17746
LD28127p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.550
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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