Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG12237LP01149p; Pyrophosphatase activity; phosphatase activity. (306 aa)    
Predicted Functional Partners:
CG9568
LP01634p.
      
 0.965
CG13102
GEO12560p1.
      
 0.918
sgll
Sugarlethal, isoform A; Sugarlethal (sgll) encodes pyridoxine 5'-phosphate oxidase (PNPO). PNPO converts pyridoxine to its active form pyridoxal 5'-phosphate (PLP). PLP is a co-factor required for more than 100 enzymes that function in amino acid metabolism, gluconeogenesis and neurotransmitter synthesis.
   
 
 0.909
CG14212
Uncharacterized protein; Phosphatase activity; pyrophosphatase activity.
  
 
 
0.908
CG31473
AT28215p; FMN binding; pyridoxamine-phosphate oxidase activity. It is involved in the biological process described with: pyridoxine biosynthetic process; pyridoxal phosphate biosynthetic process.
     
 0.906
Pdxk
Pyridoxal kinase (Pdxk) encodes the enzyme that generates Pyridoxal-5-phosphate, the metabolically active form of vitamin B6. It contributes to chromosome integrity and glucose homeostasis.
     
 0.900
Rcd-1r
Rcd-1 related; It is involved in the biological process described with: negative regulation of translation; spermatogenesis; mRNA catabolic process; reproductive process.
      
 0.824
e(y)3
Enhancer of yellow 3 (e(y)3) encodes a nuclear protein required for embryogenesis and oogenesis. It participates in gene activation in euchromatin as a component of both the SWI/SNF chromatin remodeling complex and the TFIID transcription coactivator. It also contributes to gene silencing in pericentric heterochromatin and is also a coactivator in the JAK/STAT pathway.
   
  
 0.654
Rcd-1
Required for cell differentiation 1, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process.
      
 0.598
CG12746
RE23632p; Phosphatase activity; phosphatidate phosphatase activity. It is involved in the biological process described with: phospholipid metabolic process; phospholipid dephosphorylation; signal transduction.
      
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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