STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pmp70Peroxisomal membrane protein 70 kDa, isoform A; Protein homodimerization activity; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: long-chain fatty acid import into peroxisome. (665 aa)    
Predicted Functional Partners:
spn-A
DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand.
    
 
 0.996
Pex19
Peroxin 19, isoform A; Peroxisome membrane targeting sequence binding. It is involved in the biological process described with: nervous system development; protein import into peroxisome membrane; peroxisome organization.
    
 0.983
ABCD
ATP-binding cassette sub-family D member; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
  
0.940
Pex5
Peroxin 5, isoform A; Peroxisome matrix targeting signal-1 binding. It is involved in the biological process described with: protein import into peroxisome matrix, docking; response to anesthetic; peroxisome organization.
   
  
 0.928
Pex16
Peroxin 16 (Pex16) encodes a protein involved in peroxisome organization, spermatocyte division, and fatty acid catabolism.
   
 
 0.892
Pex3
Peroxin 3 (Pex3) encodes a peroxisomal membrane protein (PMP) involved in de novo peroxisome biogenesis from the endoplasmic reticulum and PMP import from the cytosol. It also facilitates the insertion of proteins into the membrane of mature peroxisomes via its interaction with the PMP chaperone encoded by Pex19.
   
 0.891
Pex13
Peroxin 13 (Pex13) encodes a peroxisome protein important for sperm development.
   
 
 0.874
PMP34
Peroxisomal membrane protein 34, isoform A; Belongs to the mitochondrial carrier (TC 2.A.29) family.
   
 
 0.837
Pex12
Peroxin 12 (Pex12) encodes a peroxisome protein important for sperm development; Belongs to the pex2/pex10/pex12 family.
   
 
 0.833
Pex11
Peroxin 11; It is involved in the biological process described with: regulation of peroxisome size; peroxisome fission; peroxisome organization.
   
 
 0.799
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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