pico protein (fruit fly) - STRING interaction network
"pico" - Pico, isoform A in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
picoPico, isoform A; Pico is an intracellular adapter protein belonging to the MRL family of proteins, which transduce signals from growth factor receptors to changes in the actin cytoskeleton. Pico roles include the regulation of growth and cell migration (1162 aa)    
Predicted Functional Partners:
Protein enhancer of sevenless 2B; Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex; Belongs to the GRB2/sem-5/DRK family (211 aa)
Ras-like protein 3; Rap1 GTPase is a small GTPase in the Ras superfamily. When GTP bound, it binds to a number of different effectors, one of which is cno. Together they regulate many morphogenetic movements from mesoderm invagination to dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs (184 aa)
Protein enabled; Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics; Belongs to the Ena/VASP family (980 aa)
Tyrosine-protein kinase Src64B; Src oncogene at 64B is a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of Src42A (552 aa)
Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family (271 aa)
SHC-adaptor protein; It is involved in the biological process described with- epidermal growth factor receptor signaling pathway; melanotic encapsulation of foreign target; tracheal outgrowth, open tracheal system; torso signaling pathway; TORC1 signaling (409 aa)
Focal Adhesion Kinase (FAK) is a non-Receptor Tyrosine kinase (nRTK) that is involved in signaling and cytoskeletal dynamics integrating signals from RTKs and integrins. Its function has been described in multiple contexts including embryonic muscle attachement, morphogensis of the optic stalk, synaptic growth and transmission, and in the regulation of RTK-MAP kinase signaling in epithelia (1500 aa)
Rhea, isoform B; Rhea is fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins- repressing E-cadherin shg transcription in follicle cells (2836 aa)
Tyrosine-protein kinase shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] (939 aa)
Protein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development (1596 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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