| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FASN1 | Hmgcr | FBpp0307371 | FBpp0083842 | Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | 0.808 |
| FASN1 | SREBP | FBpp0307371 | FBpp0074643 | Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.942 |
| Fs(2)Ket | SREBP | FBpp0294037 | FBpp0074643 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.922 |
| Hmgcr | FASN1 | FBpp0083842 | FBpp0307371 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. | 0.808 |
| Hmgcr | Npc1a | FBpp0083842 | FBpp0079547 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. | 0.814 |
| Hmgcr | Npc1b | FBpp0083842 | FBpp0076932 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. | 0.489 |
| Hmgcr | S2P | FBpp0083842 | FBpp0087169 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity. | 0.483 |
| Hmgcr | SREBP | FBpp0083842 | FBpp0074643 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.977 |
| Hnf4 | MED15 | FBpp0079350 | FBpp0077722 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] | 0.831 |
| Hnf4 | SREBP | FBpp0079350 | FBpp0074643 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.896 |
| MED15 | Hnf4 | FBpp0077722 | FBpp0079350 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.831 |
| MED15 | SREBP | FBpp0077722 | FBpp0074643 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.973 |
| Npc1a | Hmgcr | FBpp0079547 | FBpp0083842 | Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | 0.814 |
| Npc1a | Npc1b | FBpp0079547 | FBpp0076932 | Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. | 0.907 |
| Npc1a | SREBP | FBpp0079547 | FBpp0074643 | Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.955 |
| Npc1b | Hmgcr | FBpp0076932 | FBpp0083842 | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. | 0.489 |
| Npc1b | Npc1a | FBpp0076932 | FBpp0079547 | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. | Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization. | 0.907 |
| Npc1b | SREBP | FBpp0076932 | FBpp0074643 | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. | 0.877 |
| S1P | S2P | FBpp0078120 | FBpp0087169 | Serine-type endopeptidase activity. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; proteolysis. | Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity. | 0.913 |
| S1P | SCAP | FBpp0078120 | FBpp0085363 | Serine-type endopeptidase activity. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; proteolysis. | SREBP cleavage activating protein; Sterol binding. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; protein processing; SREBP signaling pathway. | 0.814 |
