Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Grasp65Grasp65 (Grasp65) encodes a myristoylated Golgi protein that binds the product of GM130 and has been shown to mediate the Golgi bypass of transmembrane proteins. (460 aa)    
Predicted Functional Partners:
CG9356
GH05665p; It is involved in the biological process described with: Golgi organization; Golgi to plasma membrane protein transport.
   
 0.997
GM130
Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis.
   
 0.996
p115
General vesicular transport factor p115; Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae. Belongs to the VDP/USO1/EDE1 family.
   
 0.989
Sec23
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
   
 0.976
Sec24AB
Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport.
   
 
 0.941
Lamp1
FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle.
    
 0.936
Rab1
FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis.
    
 0.924
Atg8a
Autophagy-related 8a (Atg8a) encodes a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a product has roles in autophagosome formation, maintaining neuromuscular function and normal lifespan.
     
 0.923
Atg8b
Autophagy-related 8b, isoform A; Microtubule binding; protein tag; ubiquitin protein ligase binding; GABA receptor binding. It is involved in the biological process described with: macroautophagy; autophagosome maturation; cellular response to nitrogen starvation; autophagy of mitochondrion; autophagosome assembly.
     
 0.922
Syx5
Syntaxin-5; Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis.
   
 0.916
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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