STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
flnFlightin (fln) encodes an indirect flight muscle specific protein, not expressed in other muscle types. It is required for the correct assembly of the myosin thick filament during flight muscle development in pupae. fln null mutants cannot fly and show a progressive flight muscle loss as adults. This loss is most likely caused by uncontrolled hypercontraction. (182 aa)    
Predicted Functional Partners:
TpnC4
Troponin C isoform 4 (TpnC4) encodes a calcium-binding subunit in the troponin complex of flight muscle. Together with the other troponin subunits, it activates the muscle when it is stretched, leading to rapid oscillatory contractions.
   
 
 0.994
Act88F
Actin, indirect flight muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils; Belongs to the actin family.
   
 
 0.985
Strn-Mlck
Stretchin-Mlck, isoform U; Stretchin-Mlck (Strn-Mlck) encodes a complex locus producing many large protein isoforms, which likely regulate cytoskeletal dynamics in muscles. A shorter isoform is specifically expressed in indirect flight muscle, localizes to the thick filament and is required to prevent flight muscle hypercontraction. Strn-Mlck mutants cannot fly and show flight muscle atrophy.
   
 
 0.958
TpnC41C
Troponin C at 41C (TpnC41C) is expressed predominantly in the pupal and adult tubular muscles, with minor amounts in the flight muscle. The encoded protein binds calcium to regulate muscle contraction. Its absence in tubular muscle is compensated by up-regulation of the product of TpnC4.
   
  
 0.929
Mhc
Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains.
   
 
 0.875
Scp1
Sarcoplasmic calcium-binding protein 1, isoform A; Calcium ion binding.
   
    0.826
Mlp60A
Muscle LIM protein at 60A (Mlp60A) encodes a Zinc-ion binding protein, expressed strongly in the Z-band region of the sarcomere. It is involved in development and maintenance of the embryonic and flight muscles.
   
  
 0.790
CG34172
HDC00331; Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial respirasome assembly; regulation of oxidative phosphorylation.
   
 
 0.711
CG15617
FI06453p; Muscle alpha-actinin binding; actin binding. It is involved in the biological process described with: actin cytoskeleton organization; muscle structure development.
   
    0.690
bt
Bent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle.
   
  
 0.684
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.