STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rab8Rab8, isoform A; Rab8 (Rab8) encodes a member of the Rab GTPase family that regulates the function of the recycling endosome, where it localizes. (207 aa)    
Predicted Functional Partners:
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
   
 0.953
Rab39
Rab39, isoform A; GTPase activity; protein binding; GTP binding. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport.
  
0.920
Sec15
Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
    
 0.911
strat
Guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side o [...]
    
 
 0.880
Sec10
Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC10 family.
 
 
 0.877
Sec8
Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Involved in regulation of synaptic microtubule formation, and also regulation of synaptic growth and glutamate receptor trafficking. Does not appear to be required for basal neurotransmission.
    
 0.873
IFT20
Intraflagellar transport 20; It is involved in the biological process described with: centrosome localization; intraciliary transport; cilium assembly; protein localization to cilium.
   
 
 0.868
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
   
 0.850
Sec6
Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC6 family.
    
 0.833
Sec3
Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC3 family.
   
 0.822
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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