node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG17760 | CG30054 | FBpp0110121 | FBpp0291583 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 0.909 |
CG17760 | Galphao | FBpp0110121 | FBpp0089316 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. | 0.587 |
CG17760 | Galphaq | FBpp0110121 | FBpp0305314 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | 0.553 |
CG17760 | Galphas | FBpp0110121 | FBpp0072052 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. | 0.650 |
CG17760 | Gbeta76C | FBpp0110121 | FBpp0074717 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit. | 0.985 |
CG17760 | Ggamma1 | FBpp0110121 | FBpp0087726 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. | 0.736 |
CG17760 | Ggamma30A | FBpp0110121 | FBpp0312039 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit gamma-e; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye. | 0.986 |
CG17760 | ninaE | FBpp0110121 | FBpp0083266 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.914 |
CG17760 | norpA | FBpp0110121 | FBpp0290690 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.921 |
CG30054 | CG17760 | FBpp0291583 | FBpp0110121 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 0.909 |
CG30054 | Cirl | FBpp0291583 | FBpp0302596 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.772 |
CG30054 | Galphao | FBpp0291583 | FBpp0089316 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. | 0.571 |
CG30054 | Galphaq | FBpp0291583 | FBpp0305314 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. | 0.562 |
CG30054 | Galphas | FBpp0291583 | FBpp0072052 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. | 0.620 |
CG30054 | Gbeta76C | FBpp0291583 | FBpp0074717 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit. | 0.979 |
CG30054 | Ggamma1 | FBpp0291583 | FBpp0087726 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. | 0.740 |
CG30054 | Ggamma30A | FBpp0291583 | FBpp0312039 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Guanine nucleotide-binding protein subunit gamma-e; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye. | 0.978 |
CG30054 | ninaE | FBpp0291583 | FBpp0083266 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.914 |
CG30054 | norpA | FBpp0291583 | FBpp0290690 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.923 |
Cirl | CG30054 | FBpp0302596 | FBpp0291583 | Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 0.772 |