STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OatOrnithine aminotransferase, mitochondrial; Ornithine-oxo-acid transaminase activity; identical protein binding; pyridoxal phosphate binding. It is involved in the biological process described with: arginine catabolic process to proline via ornithine; ornithine metabolic process; arginine catabolic process to glutamate. (431 aa)    
Predicted Functional Partners:
arg
Arginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay.
  
 0.995
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  
 0.978
Odc1
Ornithine decarboxylase 1; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
    
 0.956
Ass
ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.949
Argl
Argininosuccinate lyase activity. It is involved in the biological process described with: arginine biosynthetic process via ornithine.
  
  
 0.948
Odc2
Ornithine decarboxylase 2; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 0.947
CG6661
GH20963p; 1-pyrroline-5-carboxylate dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: proline metabolic process; proline catabolic process to glutamate; oxidation-reduction process.
  
 0.939
P5CDh1
delta-1-Pyrroline-5-carboxylate dehydrogenase 1 (P5CDh1) encodes a conserved, nuclear-encoded mitochondrial matrix enzyme. It is a member of the aldehyde dehydrogenase superfamily involved in proline degradation.
  
 0.939
P5cr-2
Pyrroline-5-carboxylate reductase activity. It is involved in the biological process described with: oxidation-reduction process; L-proline biosynthetic process.
  
  
 0.780
P5cr
Pyrroline-5-carboxylate reductase activity. It is involved in the biological process described with: oxidation-reduction process; L-proline biosynthetic process.
  
  
 0.760
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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