STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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lushGeneral odorant-binding protein lush; Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by [...] (153 aa)    
Predicted Functional Partners:
Obp83b
Pheromone-binding protein-related protein 6; Odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus.
   
  
 0.984
Obp83a
General odorant-binding protein 83a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus; sensory perception of smell.
   
  
 0.972
Obp69a
General odorant-binding protein 69a; Odorant-binding protein required for olfactory behavior and activity of pheromone-sensitive neurons in response to the male- specific pheromone cis-vaccenyl acetate (cVA). Modulates social responsivity differently in males and females, regulating male aggression and female receptivity respectively.
   
  
 0.967
Or67d
Odorant receptor 67d; Plays a role in detection and sensitivity to pheromones and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to othe [...]
   
 
 0.953
Opbp
Optix-binding protein (Opbp) encodes a Zn finger protein that can bind to the Six-family transcription factor encoded by Optix.
      
 0.937
Obp84a
General odorant-binding protein 84a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of chemical stimulus.
   
  
 0.929
a10
Putative odorant-binding protein A10.
   
  
 0.914
Obp28a
General odorant-binding protein 28a; Pheromone binding; odorant binding. It is involved in the biological process described with: sensory perception of smell; sensory perception of chemical stimulus.
   
  
 0.883
Obp19a
General odorant-binding protein 19a; Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
   
  
0.876
Snmp1
Sensory neuron membrane protein 1; Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the developmen [...]
   
  
 0.849
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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