Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG6843Cir_N domain-containing protein; Transcription corepressor activity. It is involved in the biological process described with: negative regulation of transcription, DNA-templated. (366 aa)    
Predicted Functional Partners:
CG6066
NKAP family protein CG6066; Chromatin binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; Notch signaling pathway; negative regulation of transcription, DNA-templated; Belongs to the NKAP family.
   
 
 0.991
Su(H)
Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...]
   
 0.986
Cwc25
LD47748p; It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 
 0.937
HDAC1
Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...]
   
 0.892
CG14323
FI16123p1.
      
 0.863
Bx42
Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway.
   
 
 0.802
CG5877
Uncharacterized protein, isoform A; It is involved in the biological process described with: mRNA splicing, via spliceosome; heterochromatin assembly by small RNA; RNA interference.
      
 0.758
CG31211
Uncharacterized protein, isoform B.
    
 
 0.748
CtBP
C-terminal-binding protein; Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
  
 0.713
CG6724
Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family.
 
 
    0.690
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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