STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)    
Predicted Functional Partners:
muc
Midline uncoordinated, isoform B; Pyruvate dehydrogenase (NAD+) activity; dihydrolipoyllysine-residue acetyltransferase activity. It is involved in the biological process described with: grooming behavior; acetyl-CoA biosynthetic process from pyruvate.
 0.999
CG5214
GM01350p; Dihydrolipoyllysine-residue succinyltransferase activity. It is involved in the biological process described with: cellular respiration; tricarboxylic acid cycle.
 0.999
Pdhb
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.999
CG5599
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Acetyltransferase activity; lipoic acid binding.
 
 0.998
Nc73EF
Neural conserved at 73EF, isoform I; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle.
  
 0.997
CG1544
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
  
 0.994
CG17691
Uncharacterized protein, isoform C; Alpha-ketoacid dehydrogenase activity. It is involved in the biological process described with: response to nutrient; fatty-acyl-CoA biosynthetic process; branched-chain amino acid catabolic process.
 
 0.994
Pdha
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 
 0.991
CG8199
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.989
CG7024
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 
 0.987
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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