STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUCB1NUCB1 (NUCB1) encodes a protein involved in the defense response to Gram-negative bacteria. (569 aa)    
Predicted Functional Partners:
CG10943
Uncharacterized protein.
      
 0.837
CG8008
Uncharacterized protein, isoform B; It is involved in the biological process described with: transmembrane transport.
      
 0.792
Acbp3
fatty-acyl-CoA binding.
      
 0.666
TM4SF
Tetraspanin.
      
 0.661
CG15096
RE40577p; Transmembrane transporter activity. It is involved in the biological process described with: anion transport; transmembrane transport.
      
 0.628
CG2233
GH20802p.
      
 0.607
Ilp8
Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing.
      
 0.601
S2P
Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity.
      
 0.515
Herp
It is involved in the biological process described with: endoplasmic reticulum unfolded protein response.
   
  
 0.514
scf
Supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein.
   
 
 0.508
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.