Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NUCB1NUCB1 (NUCB1) encodes a protein involved in the defense response to Gram-negative bacteria. (569 aa)    
Predicted Functional Partners:
CG10943
Uncharacterized protein.
      
 0.814
scf
Supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein.
   
 
 0.777
S2P
Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; sterol regulatory element binding protein cleavage; membrane protein intracellular domain proteolysis; positive regulation of DNA-binding transcription factor activity.
      
 0.700
Herp
It is involved in the biological process described with: endoplasmic reticulum unfolded protein response.
      
 0.679
Surf4
Surfeit locus protein 4 homolog; Belongs to the SURF4 family.
   
  
 0.661
CG8008
Uncharacterized protein, isoform B; It is involved in the biological process described with: transmembrane transport.
      
 0.655
AstA-R1
Allatostatin A receptor 1 (AstA-R1) encodes a G-protein coupled receptor for the neuropeptide encoded by AstA.
      
 0.639
TM4SF
Tetraspanin.
      
 0.594
Ubc7
Ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of innate immune response; protein polyubiquitination; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process; defense response to Gram-negative bacterium.
   
  
 0.592
Acbp3
fatty-acyl-CoA binding.
      
 0.581
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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