Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG7484CG7484 protein; Oxidoreductase activity; disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. (178 aa)    
Predicted Functional Partners:
SelT
Thioredoxin reductase-like selenoprotein T homolog CG3887; Probably has thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. SELT subfamily.
   
  
 0.984
Uggt
UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family.
   
 
 0.972
SelR
Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.
      
 0.837
SelG
Selenoprotein G (SelG) encodes a type III Golgi apparatus transmembrane protein. It is implicated in the release of Ca[2+] from the endoplasmic reticulum to the cytosol by regulating the expression of genes participating in the inositol 1,4,5-tris-phosphate pathway.
   
  
 0.789
kmg
LP08967p; Kumgang (kmg) encodes a protein that exhibits chromatin binding activity. It is involved in regulation of gene expression and spermatogenesis.
    
   0.789
Yip1d1
Protein YIPF; It is involved in the biological process described with: positive regulation of synapse pruning; spermatogenesis.
   
  
 0.776
eEFSec
Eukaryotic translation elongation factor, selenocysteine-specific (eEFSec) encodes a protein involved in the incorporation of selenocysteine during protein translation.
      
 0.772
CG33116
FI05338p; Phosphotransferase activity, for other substituted phosphate groups; ethanolaminephosphotransferase activity. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
      
 0.753
CG1840
LD12750p; It is involved in the biological process described with: calcium ion transport; endoplasmic reticulum calcium ion homeostasis.
   
  
 0.729
BthD
Selenoprotein BthD; May be involved in a redox-related process. Required for survival and specifically for salivary gland morphogenesis.
   
  
 0.720
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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