Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Adgf-AAdenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. (553 aa)    
Predicted Functional Partners:
Adk2
Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
   
 0.942
Adk1
AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
    
 0.926
Adk3
GM02629p; Adenosine kinase activity.
    
 0.926
CG18128
FI08065p; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process.
    
 0.920
CG16758
Uncharacterized protein, isoform H; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process.
    
 0.920
CG11050
Uncharacterized protein, isoform A; 5'-deoxynucleotidase activity.
   
 
  0.903
dnk
Deoxynucleoside kinase; Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.
     
 0.901
AdoR
Adenosine receptor (AdoR) encodes a protein belongsING to the G protein-coupled receptor family (Class A) that functions via cAMP and PKA activation. It is involved in response to metabolic stress and neuromodulation.
      
 0.828
NT5E-2
Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family.
  
 
 0.713
veil
Veil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family.
  
 
 0.710
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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