Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
Edc3Enhancer of mRNA-decapping protein 3; In the process of mRNA degradation, may play a role in mRNA decapping. (680 aa)    
Predicted Functional Partners:
DCP1
Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing.
   
 0.999
me31B
ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...]
   
 0.999
Ge-1
Enhancer of mRNA-decapping protein 4 homolog; In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets.
   
 0.999
DCP2
Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly.
  
 0.999
pcm
5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control.
   
 
 0.997
Patr-1
Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions.
   
 0.994
LSm1
U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.
   
 0.993
tral
Trailer hitch (tral) encodes a protein required for oocyte dorsoventral patterning via actin and microtubule cytoskeleton organization.
   
 
 0.992
CG17768
U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.
   
 0.976
Upf1
Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity).
   
 
 0.958
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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