| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AstC | Crz | FBpp0079821 | FBpp0082386 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | 0.643 |
| AstC | Dh44 | FBpp0079821 | FBpp0310724 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | 0.654 |
| AstC | Dsk | FBpp0079821 | FBpp0078628 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Drosulfakinin-0; Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae; Belongs to the gastrin/cholecystokinin family. | 0.562 |
| AstC | FMRFa | FBpp0079821 | FBpp0087471 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation. | 0.681 |
| AstC | Hug | FBpp0079821 | FBpp0082108 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.513 |
| AstC | Ilp2 | FBpp0079821 | FBpp0076058 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.536 |
| AstC | Mip | FBpp0079821 | FBpp0075003 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Allatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility. | 0.636 |
| AstC | Nplp1 | FBpp0079821 | FBpp0288531 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide-like 1; [NPLP1-4]: Acts as a ligand for the receptor-type guanylate cyclase Gyc76C. Stimulates Gyc76c-dependent cGMP production and modulates the IMD innate immune pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Does not appear to play a role in Gyc76C- mediated wing development. | 0.664 |
| AstC | Orcokinin | FBpp0079821 | FBpp0072118 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Orcokinin, isoform A. | 0.842 |
| AstC | SIFa | FBpp0079821 | FBpp0293592 | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | Neuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. | 0.674 |
| Crz | AstC | FBpp0082386 | FBpp0079821 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | 0.643 |
| Crz | Dh44 | FBpp0082386 | FBpp0310724 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | 0.801 |
| Crz | Dsk | FBpp0082386 | FBpp0078628 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Drosulfakinin-0; Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae; Belongs to the gastrin/cholecystokinin family. | 0.626 |
| Crz | FMRFa | FBpp0082386 | FBpp0087471 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation. | 0.515 |
| Crz | Hug | FBpp0082386 | FBpp0082108 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.714 |
| Crz | Ilp2 | FBpp0082386 | FBpp0076058 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.723 |
| Crz | Mip | FBpp0082386 | FBpp0075003 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Allatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility. | 0.629 |
| Crz | Orcokinin | FBpp0082386 | FBpp0072118 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Orcokinin, isoform A. | 0.557 |
| Crz | SIFa | FBpp0082386 | FBpp0293592 | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | Neuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. | 0.506 |
| Dh44 | AstC | FBpp0310724 | FBpp0079821 | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. | 0.654 |