STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scaf6SR-related CTD associated factor 6, isoform A; RNA binding. It is involved in the biological process described with: cellular calcium ion homeostasis; RNA processing. (960 aa)    
Predicted Functional Partners:
CG9346
Uncharacterized protein; RNA binding; mRNA binding. It is involved in the biological process described with: RNA processing.
   
 0.999
Sf3b3
Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing [...]
   
 0.999
Spf45
RNA binding motif protein 17; Spf45 (Spf45) encodes a bi-functional protein with roles in both splicing and DNA repair.
   
 0.999
Sf3b1
Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 0.999
Sf3b2
Splicing factor 3b subunit 2, isoform A; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.999
Spx
Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.998
Sf3a2
Splicing factor 3a subunit 2; RNA binding; zinc ion binding. It is involved in the biological process described with: positive regulation of gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 0.998
SNRPG
Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly. Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity).
   
 0.996
CG6686
RE11167p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; positive regulation of gene expression; maturation of 5S rRNA.
   
 
 0.993
CG17168
RE68879p; RNA binding; mRNA binding. It is involved in the biological process described with: production of miRNAs involved in gene silencing by miRNA.
   
 
 0.993
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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