STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
l(3)72AbPutative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2142 aa)    
Predicted Functional Partners:
CG4849
LD28793p; U5 snRNA binding; GTP binding; GTPase activity; translation elongation factor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; translational elongation; positive regulation of gene expression.
   
 0.999
Prp8
pre-mRNA processing factor 8 (Prp8) is an essential gene that encodes the largest and most highly conserved splicing factor. It is a core component of the U5 snRNP, with a key function in pre-mRNA processing catalyzed by the spliceosome.
   
 0.999
CG6841
LD04472p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; regulation of alternative mRNA splicing, via spliceosome.
   
 0.999
Sf3b3
Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing [...]
   
 
 0.997
Dim1
Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family.
    
 0.997
CG6015
LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
    
 
 0.996
Sf3b1
Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 
 0.996
Bx42
Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway.
   
 
 0.996
CG3436
GM13767p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mitotic cell cycle.
   
 0.996
Prp3
Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing.
   
 
 0.995
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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