| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG7907 | Fs(2)Ket | FBpp0112173 | FBpp0294037 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | 0.733 |
| CG7907 | Ran-like | FBpp0112173 | FBpp0075369 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. | 0.919 |
| CG7907 | RanGAP | FBpp0112173 | FBpp0080775 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.402 |
| CG7907 | emb | FBpp0112173 | FBpp0079278 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. | 0.561 |
| Fs(2)Ket | CG7907 | FBpp0294037 | FBpp0112173 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. | 0.733 |
| Fs(2)Ket | Nup358 | FBpp0294037 | FBpp0293235 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | 0.940 |
| Fs(2)Ket | Ran-like | FBpp0294037 | FBpp0075369 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. | 0.930 |
| Fs(2)Ket | RanGAP | FBpp0294037 | FBpp0080775 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.890 |
| Fs(2)Ket | Ranbp21 | FBpp0294037 | FBpp0309478 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus. | 0.572 |
| Fs(2)Ket | emb | FBpp0294037 | FBpp0079278 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. | 0.778 |
| Ntf-2r | Nup358 | FBpp0080616 | FBpp0293235 | Nuclear transport factor-2-related; It is involved in the biological process described with: protein import into nucleus; nucleocytoplasmic transport. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | 0.494 |
| Ntf-2r | Ran-like | FBpp0080616 | FBpp0075369 | Nuclear transport factor-2-related; It is involved in the biological process described with: protein import into nucleus; nucleocytoplasmic transport. | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. | 0.919 |
| Ntf-2r | RanGAP | FBpp0080616 | FBpp0080775 | Nuclear transport factor-2-related; It is involved in the biological process described with: protein import into nucleus; nucleocytoplasmic transport. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.414 |
| Nup358 | Fs(2)Ket | FBpp0293235 | FBpp0294037 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | 0.940 |
| Nup358 | Ntf-2r | FBpp0293235 | FBpp0080616 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Nuclear transport factor-2-related; It is involved in the biological process described with: protein import into nucleus; nucleocytoplasmic transport. | 0.494 |
| Nup358 | Ran-like | FBpp0293235 | FBpp0075369 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. | 0.961 |
| Nup358 | RanGAP | FBpp0293235 | FBpp0080775 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.999 |
| Nup358 | Ranbp21 | FBpp0293235 | FBpp0309478 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus. | 0.761 |
| Nup358 | eEF5 | FBpp0293235 | FBpp0072082 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis; Belongs to the eIF-5A family. | 0.414 |
| Nup358 | emb | FBpp0293235 | FBpp0079278 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. | 0.995 |