STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG6888AT16346p; Thioredoxin peroxidase activity. (196 aa)    
Predicted Functional Partners:
Jafrac1
Peroxiredoxin 1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...]
  
  
0.902
CG6762
Putative sulfiredoxin; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (By similarity); Belongs to the sulfiredoxin family.
   
 
 0.849
Prx5
Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis.
   
 0.844
CG8517
GEO08746p1; Protein disulfide oxidoreductase activity; disulfide oxidoreductase activity. It is involved in the biological process described with: glycerol ether metabolic process; cell redox homeostasis.
  
 
 0.841
Trx-2
Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.
  
 0.839
CG13473
GEO12009p1; Protein-disulfide reductase activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; disulfide oxidoreductase activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis.
  
 
 0.750
Prosbeta4R1
Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process.
   
  
 0.735
TrxT
Thioredoxin-T; Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.
  
 
 0.703
CG10749
L-malate dehydrogenase activity. It is involved in the biological process described with: carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle.
  
 
 0.692
CG9314
CG9314 protein; Catalase activity; heme binding. It is involved in the biological process described with: response to oxidative stress; hydrogen peroxide catabolic process; response to hydrogen peroxide; oxidation-reduction process.
  
 
 0.677
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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