STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG5048AT12351p; Chaperone binding. It is involved in the biological process described with: flagellated sperm motility. (210 aa)    
Predicted Functional Partners:
CG14921
AT10515p; It is involved in the biological process described with: cilium movement; inner dynein arm assembly; outer dynein arm assembly; sensory perception of sound.
   
 
 0.845
Nop17l
Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily.
    
 
 0.817
goddard
GEO12017p1; Goddard (goddard) is a newly evolved gene that encodes a predicted disordered protein with no homology to other protein families. It is implicated in male reproduction, as males with reduced goddard expression fail to produce sperm.
   
  
 0.815
CG4546
GH24918p; Kinase activity; creatine kinase activity. It is involved in the biological process described with: multicellular organism reproduction; phosphocreatine biosynthetic process; Belongs to the ATP:guanido phosphotransferase family.
   
    0.813
Dnali1
Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility.
   
  
 0.772
CG18662
Protein histidine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; peptidyl-histidine dephosphorylation.
   
    0.761
Upf1
Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity).
   
 
 0.753
CG17564
GH10882p.
   
  
 0.751
Wdr92
WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade.
      
 0.712
COX4L
Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen.
   
  
 0.704
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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