STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development. (382 aa)    
Predicted Functional Partners:
CG5674
RH05790p.
    
   0.994
CG4318
IP01435p; Zinc ion binding; DNA-binding transcription factor activity; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
    
 
 0.994
lwr
Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo.
    
   0.994
lms
Lateral muscles scarcer, isoform B; Lateral muscles scarcer (lms) encodes a homeodomain transcription factor that is an identity factor for lateral transverse muscles.
   
   0.994
Sox21a
Sox21a, isoform B; Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut.
  
 
0.869
vvl
POU domain protein CF1A; Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Belongs to the POU transcription factor family. Class-3 subfamily.
   
 
 0.857
SoxN
SoxNeuro, isoform B; SoxNeuro (SoxN) encodes an HMG-domain transcription factor. In early embryos it specifies neural progenitors in the central nervous system, while in later embryos it negatively regulates Wg signaling and controls expression of genes required for denticle construction with the product of ovo.
  
0.801
pdm2
POU domain protein 2, isoform B; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
   
 
 0.743
nub
Protein nubbin; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins. Belongs to the POU transcription factor family. Class-2 subfamily.
   
 
 0.701
mei-217
Mei-217 (mei-217) is encoded on the same mRNA as the product of mei-218. The products of mei-217 and mei-218 interact physically and are involved in meiotic recombination.
      
 0.669
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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