Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DDichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development. (382 aa)    
Predicted Functional Partners:
CG5674
RH05790p.
    
   0.999
CG4318
IP01435p; Zinc ion binding; DNA-binding transcription factor activity; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
    
   0.999
lwr
Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo.
    
   0.999
lms
Lateral muscles scarcer, isoform B; Lateral muscles scarcer (lms) encodes a homeodomain transcription factor that is an identity factor for lateral transverse muscles.
   
   0.999
Sox21a
Sox21a, isoform B; Sox21a (Sox21a) encodes a Sox family transcription factor involved in the differentiation of stem cells in the midgut.
  
 
0.989
SoxN
SoxNeuro, isoform B; SoxNeuro (SoxN) encodes an HMG-domain transcription factor. In early embryos it specifies neural progenitors in the central nervous system, while in later embryos it negatively regulates Wg signaling and controls expression of genes required for denticle construction with the product of ovo.
  
0.929
vvl
POU domain protein CF1A; Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Belongs to the POU transcription factor family. Class-3 subfamily.
    
 
 0.924
pdm2
POU domain protein 2, isoform B; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
   
 
 0.903
trh
Protein trachealess; Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles. It may induce a general fate of branched tubular structures of epithelial origin. Functions with tgo to regulate expression of btl.
   
 
 0.894
nub
Protein nubbin; DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins. Belongs to the POU transcription factor family. Class-2 subfamily.
   
 
 0.882
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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