STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCTN1-p150Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa)    
Predicted Functional Partners:
DCTN2-p50
Dynactin 2, p50 subunit (DCTN2-p50) encodes a subunit of the dynactin complex. Together with other members of the dynactin complex, the product of DCTN2-p50 is critical for most functions of the minus end-directed microtubule motor cytoplasmic dynein-1, including oocyte polarity, mRNA localization, centrosome localizations, spindle organization, endocytosis and axonal transport.
   
 
 0.994
DCTN3-p24
Dynactin 3, p24 subunit, isoform A; It is involved in the biological process described with: cytoskeleton-dependent cytokinesis; regulation of hemocyte proliferation.
   
 
 0.976
Arp1
Actin-related protein 1 (Arp1) encodes the short filamentous component of the Dynactin complex, which plays an essential role in the activation of the Dynein microtubule motor protein. As such, the Arp1 product is required for diverse cellular processes such as intracellular transport, mitotic spindle assembly, chromosome movements, and nuclear positioning.
   
 
 0.955
Arp10
Actin-related protein 10 (Arp10) encodes a component of the dynactin multiprotein complex that is involved in microtubule-based movement; Belongs to the actin family.
   
 
 0.955
DCTN4-p62
Dynactin 4, p62 subunit.
   
 
 0.954
sw
Cytoplasmic dynein 1 intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
    
 
 0.907
DCTN6-p27
Dynactin 6, p27 subunit.
    
 
 0.892
Dhc64C
Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis.
   
 
 0.889
DCTN5-p25
Dynactin 5, p25 subunit (DCTN5-p25) encodes a motor protein involved in spermatogenesis. It also contributes to the dendritic restriction of the product of Dscam1.
    
 
 0.887
cpb
Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.
    
 
 0.858
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.